By Margaret Kielian, Thomas Mettenleiter, Marilyn Roossinck
Published because 1953, Advances in Virus Research covers a various diversity of in-depth studies, delivering a precious assessment of the present box of virology.
- Contain contributions from prime authorities
- Informs and updates on all of the most up-to-date advancements within the box of virology
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Extra info for Advances in Virus Research
This combined strategy minimizes both false positive and false negatives and is useful for identifying highconfidence HRV-HFs. Functional Genomic Strategies for Elucidating Human–Virus Interactions 37 Figure 3 CRISPR/Cas9 screen for HRV host factors. (A) The HRV-HF CRISPR/Cas9 screen workflow showing the generation of the Cas9 expressing H1-HeLa cells containing the sgRNA libraries followed by their subsequent challenge with HRV14 and the assessment of the enriched sgRNAs using next-gen sequencing.
John, S. , Huang, Y. , Chin, C. , et al. (2013). A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication. Gastroenterology, 144, 1438–1449. Gilbert, L. , Horlbeck, M. , Villalta, J. , Whitehead, E. , et al. (2014). Genome-scale CRISPR-mediated control of gene repression and activation. Cell, 159, 647–661. , & Mello, C. C. (2002). RNAi (Nematodes: Caenorhabditis elegans). Advances in Genetics, 46, 339–360. , Newton, M. , & Ahlquist, P. (2013).
Stiles, K. , Liu, C. , Taylor, G. , & Kielian, M. (2013). Genome-wide RNAi screen identifies novel host proteins required for alphavirus entry. PLoS Pathogens, 9, e1003835. Functional Genomic Strategies for Elucidating Human–Virus Interactions 49 Organ, E. , Ruley, H. , & Rubin, D. H. (2004). Discovery of mammalian genes that participate in virus infection. BMC Cell Biology, 5, 41. Ortblad, K. , & Murray, C. J. (2013). The burden of HIV: Insights from the Global Burden of Disease Study 2010. AIDS, 27, 2003–2017.
Advances in Virus Research by Margaret Kielian, Thomas Mettenleiter, Marilyn Roossinck