Download PDF by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.): Allergy

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By Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

ISBN-10: 0723436584

ISBN-13: 9780723436584

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The evidence for linkage of a genomic region to a phenotype of interest is usually expressed in terms of the ratio of their odds of the two hypotheses (linkage or nonlinkage), the likelihood ratio (LR), or more equivalently by the lod score (Z), where Z = log10(LR). Both parametric (involving prior specification of a genetic model) and, more commonly in complex disease, non-parametric linkage approaches such as allele sharing can be taken. Allele-sharing methods test whether the inheritance pattern of a particular chromosomal region is inconsistent with random mendelian segregation by showing that pairs of affected relatives inherit identical copies of the region more often than would be expected by chance.

Interestingly, anti-IL-5 does not significantly inhibit the LPR response to allergen challenge. 5 1 2 3 4 5 6 7 Time (h) 8 9 10 11 12 24 Fig. 31 Early and late phase responses in asthma. The asthmatic response to allergen inhalation challenge with house dust mite allergen (green line) and diluent control (red line), demonstrating both an early and a late phase allergic response. FEV1, forced expiratory volume in 1 second. EPR and LPR in the nose In the nose, topical allergen challenge of sensitized individuals causes immediate nasal reactions involving itching, sneezing, congestion, and watery discharges.

In allergic subjects the response to allergen challenge is characterized by an immediate or 1 early phase response (EPR), which is followed in approximately 50% of adults and 70% of children by a late phase response (LPR) (see Fig. 32). The EPR is initiated by the release of mast cell mediators following allergen challenge of a sensitized individual. g. bronchoconstriction in the lower airways, rhinorrhoea and congestion in the nose, and a wheal and flare response in the skin). The EPR generally develops within approximately 10 minutes of allergen exposure, reaching a maximum at 30 minutes, and resolving within 1–2 hours.

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Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

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