By C.C. Reddy (Eds.)
The second one of 2 volumes proposing present study into oxidation platforms, this e-book is meant for biochemists, toxicologists, and pharmacologists. issues mentioned comprise oxidation mechanisms in carcinogenesis, lipid peroxidation and different non-enzymatic reactions of oxygen
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Extra resources for Biological Oxidation Systems. Volume 2
These products were also cytotoxic. Hypochlorite also formed similar products with p-phenetidine. Furthermore as can be seen in table 2, hypochlorite markedly activated phenetidine to cytotoxic products. Chloroperoxidise and H 2 0 2 also activated p-phenetidine to cytotoxic products. Other investigators have identified the products formed when phenetidine is oxidized by H 2 0 2 and horseradish peroxidase (41). The 253, 260nm products formed when phenetidine is oxidized by hypochlorite had an identical spectra to benzoquinoneimine synthesised as previously described (38).
P~Phenetidine Oxidation by Lactoperoxidase: H2P2 in the presence and absence of KBr. 5 and the spectra recorded after 5 minutes. hepatocytes. Rat liver microsomes however had twenty fold less specific activity than hamster microsomes at N-deacetylating Nhydroxyphenacetin (42). N-Hydroxy-acetylaminofluorene was much more cytotoxic in isolated hepatocytes (results not shown) probably because it was more readily N-deacetylated(40). p-Phenetidine also became cytotoxic in the presence of chloroperoxidase and H 2 0 2 .
Quercetin, applied topically to the skin of CD-I mice at a dose level of 30 μχαο\ per mouse significantly inhibited the promoting effect of 12-0-tetradecanoylphorbol-13-acetate (TPA) on DMBAinduced skin tumors (26). Similar effects on the inhibition of TPA actions were observed with morin, kaempferol, and fisetin (27). Quercetin strongly inhibits mouse skin lipoxygenase, an observation in agreement with previous studies on the inhibition, by various flavonoids, of lipoxygenase and prostaglandin synthetase (28), and its antipromotional activity could well be due to an effect at this locus.
Biological Oxidation Systems. Volume 2 by C.C. Reddy (Eds.)