Download PDF by Vishal S. Vaidya, Joseph V. Bonventre: Biomarkers: In Medicine, Drug Discovery, and Environmental

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By Vishal S. Vaidya, Joseph V. Bonventre

ISBN-10: 0470452242

ISBN-13: 9780470452240

This ebook presents an creation to the sphere of biomarkers, how they've been and will be used, and the way various ways can be utilized to spot, represent, and video display biomarkers. The e-book has chapters on subject matters together with HIV, melanoma, Parkinson’s, vascular damage, environmental publicity. A following part discusses the applied sciences (diagnostics and assays) to become aware of biomarkers and authors have emphasised the preclinical and medical manifestation of the injury/disease method.

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Extra resources for Biomarkers: In Medicine, Drug Discovery, and Environmental Health

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For example, as noted above, MammaPrint® is an FDA-approved test that examines gene expression in breast cancer tissue and provides the physician and patient with a report detailing the risk of cancer recurrence. Another FDA-approved assay, AlloMap®, monitors changes in 20 genes present in circulating white blood cells to assess the risk of cardiac allograft rejection. Using gene expression alterations as biomarkers of tissue injury is not restricted to allograft rejection although, to date, the other biomarkers have not been qualified for use.

Considerable random variability); and 4) diseases that are difficult to diagnose with clinical techniques could result in false positives and false negatives within the sample. Although MAQC-I20 demonstrated the technical reliability of microarray technology in detecting differential gene expression, questions remained regarding reliability of the technology in clinical applications such as disease diagnostics or prognostics, and for tailored patient treatment based on gene expression profiles.

Pardalidis, N. , and Sofikitis N. ), J. Urol. April 2008;179(4):1271-1276. 7. Armstrong, J. A. Urinalysis in Western Culture: A Brief History, Kidney Int. March 2007;71(5):384-387. 8. Rosenfeld, L. Clinical Chemistry Since 1800: Growth and Development. Clin. Chem. January 2002;48(1): 186-197. 9. Varmus, H. Foreword, In Downing G. , Biomarkers and Surrogate Endpoints: Clinical Research and Applications. New York, NY: Elsevier; 2000. SECTION I TOOLS FOR BIOMARKER DISCOVERY This page intentionally left blank CHAPTER GENOMICS Weida Tong and Donna L.

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Biomarkers: In Medicine, Drug Discovery, and Environmental Health by Vishal S. Vaidya, Joseph V. Bonventre

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