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By Henry Gautier (auth.), Jean-Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yvette Dalmaz (eds.)

ISBN-10: 1441992804

ISBN-13: 9781441992802

ISBN-10: 1461348730

ISBN-13: 9781461348733

Since 1959, the overseas Society of Arterial Chemoreception (ISAC) has prepared in a number of nations fifteen clinical conferences dedicated to the mechanisms of peripheral arterial chemoreception and chemoreceptor reflexes. After the assembly held in Philadelphia with Sukhamay Lahiri as president, ISAC club elected Lyon (CNRS, collage Claude Bernard, France) because the web site of the xv" ISAC Symposium. The Symposium was once successfully held in Lyon from the 18th to the twenty second of November 2002 and Jean-Marc Pequignot was once its president. The organizers have been Jean-Marc Pequignot and Yvette Dalmaz Lyon (CNRS, collage Claude Bernard, France) and the medical Committee used to be shaped by way of John Carroll (University of Arkansas for scientific Sciences, USA), Constancio Gonzalez (University of Valladolid, Spain), Prem Kumar (University of Birmingham, U. okay. ), Sukhamay Lahiri (University of Pennsylvania, Philadelphia, USA), Colin Nurse (McMaster collage, Hamilton, Ontario, Canada), and Nanduri Prabhakar (Case Western collage, Cleveland, Ohio, USA). The Symposium in Lyon meant to stick with the trail opened in Philadelphia accumulating humans operating on the interface of mobile and molecular biology with researchers within the extra classical subject matters of chemoreception pathways and reflexes. the purpose was once to hitch specialists with varied views. alongside those strains, a few members are engaged within the exploration of the intimate mechanisms of oxygen sensing and mobile responses, with their paintings established in numerous arrangements masking a extensive spectrum from micro organism, to chemoreceptor cells or to principal fearful platforms neurons.

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2001). , 2001). , 2000). , 2000). , 2000). , 2000) . , 2000). , 2001). , 2001). TALK-1 and TALK-2 are background K+currents which are activated by alkaline pH, but are insensitive to arachidonic acid. , 2001). , 2001). 7. CONCLUSIONS AND PERSPECTIVES These recent findings provide strong evidence that 2P domain K+ channels are sensitive molecular targets for volatile anesthetics. , 1999). Opening of the 2P domain K+ channels is agent specific. , 2001). , 2001). , 2001). , 2000) . This difference in potency between the two volatile anesthetics indicates that opening of 2P domain K+channels will probably be prevalent during halothane-induced anesthesia .

2001). , 2001). TALK-1 and TALK-2 are background K+currents which are activated by alkaline pH, but are insensitive to arachidonic acid. , 2001). , 2001). 7. CONCLUSIONS AND PERSPECTIVES These recent findings provide strong evidence that 2P domain K+ channels are sensitive molecular targets for volatile anesthetics. , 1999). Opening of the 2P domain K+ channels is agent specific. , 2001). , 2001). , 2001). , 2000) . This difference in potency between the two volatile anesthetics indicates that opening of 2P domain K+channels will probably be prevalent during halothane-induced anesthesia .

200 I, Molecular Physiology of oxygen-sensitive potassium channels. Eur. Resp. J. I18: 221-227 . J. , 2001, Properties and modulation of mammalian 2P domain K+ channels. 24: 339-46 . , Romey , G. , 1999, Inhalational anaesthetics activate two-pore-domain background K+ channels. Nature Neurosci. 2: 422-426. , Duprat, F. , 1998, A mamm alian two pore domain mechano-gated S-like K+channel. EMBO 1. 17: 4283-4290. , Lazdunski, M. , 2001 , Lipid and mechano-gated 2P domain K+ channels. Curr Opin Cell Bioi 13: 422-8 .

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Chemoreception: From Cellular Signaling to Functional Plasticity by Henry Gautier (auth.), Jean-Marc Pequignot, Constancio Gonzalez, Colin A. Nurse, Nanduri R. Prabhakar, Yvette Dalmaz (eds.)


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