Download e-book for kindle: Critical Care Challenges - Disorders, Treatments, Procedures by J. McCann

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  • March 16, 2018
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By J. McCann

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Extra resources for Critical Care Challenges - Disorders, Treatments, Procedures

Example text

Actually, in this last condition, neutrophil counts are elevated, but lymphocyte and monocyte counts are generally depressed. Acute neutrophilia is determined by the release of neutrophils from the marrow storage pool in response to inflammation and infections. In this circumstance, immature forms including metamyelocytes are not released into the bloodstream except under extreme circumstances. 1 Causes of acute neutrophilia Causes Physical stimuli Emotional stimuli Germs Tissue inflammation/necrosis Drugs and hormones Examples Cold, heat, exercise, convulsions, pain Panic, rage, depression Localized and systemic acute bacterial, rickettsial, and spirochetal infections Trauma, burns, acute pancreatitis, electric shock, vasculitis, gout Epinephrine, glucocorticoids, tobacco, vaccines transient neutropenia, followed by neutrophilia resulting from release of marrow neutrophils.

Neutropenia can result from acute or chronic bacterial, parasitic, and viral diseases. Certain viral infections, such as infectious mononucleosis, infectious hepatitis, Parvovirus B19, and HIV infection may cause severe and protracted neutropenia and pancytopenia resulting from infection of hematopoietic precursor cells. Other agents, such as Rickettsia and Bartonella, can infect endothelial cells. These agents may cause leukopenia, neutropenia, thrombocytopenia, and anemia as part of a generalized vasculitic process.

Darmon M, Azoulay E, Alberti C (2002) Impact of neutropenia duration of short term mortality in neutropenic critical ill cancer patients. Intensive Care Med 28(12):1775–1780 46 G. Berlot et al. 4. Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012. Crit Care Med 41(2):580–637 5. Youinou P, Jamin C, Le Pottier L (2014) Diagnostic criteria for autoimmune neutropenia. Autoimmun Rev 13(4–5):547–576 6.

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Critical Care Challenges - Disorders, Treatments, Procedures by J. McCann


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